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Featured Presentation at Sample Preparation Conference Highlights Wave 80’s Technological Leadership

Dr. Shan Gao, a senior member of Wave 80’s technical staff, to speak on high-efficiency extraction of genomic material from challenging samples without centrifugation.

San Diego, California, April 18, 2013—The Sample Prep 2013 conference, to be held on May 9-10, will feature an invited talk by Wave 80’s Dr. Shan Gao, conference organizers have announced.

The presentation will highlight recent evaluation data from sample preparation modules built into disposable cartridges used with the company’s EOSCAPE next-generation molecular diagnostics platform.

EOSCAPE cartridge-integrated sample prep modules, which are less than three cubic centimeters in size and interface seamlessly with downstream cartridge components, perform the critical function of extracting DNA and RNA from the complex sample matrices which are to undergo analysis in the cartridge. Samples which can be processed range from whole blood to urine to sputum, as well as non-human material for environmental and food safety testing.

For testing with the EOSCAPE-HIV, the lead product in Wave 80’s product pipeline, a 100 microliter whole blood sample (typically from a fingerstick or heelstick) is loaded into the cartridge through a small port. The loading port is then capped, and the assay begins to runs autonomously, with the first stage of the process being the extraction of viral RNA. Unlike many nucleic acid sample preparation processes, no centrifugation is required. The cartridge is held within an EOSCAPE processing unit during the test, which supplies electrical power to the cartridge. As with the downstream assay processes, the extraction process uses fluid power generated by onboard Liquid Micropistons (LMPs).

Dr. Gao, who holds a Ph.D. in chemical engineering from Columbia University, joined Wave 80 in 2011 after holding a position as a Research Fellow at Massachusetts General Hospital. Dr. Gao’s co-authors on the talk include Dr. Catherine Klapperich and Dr. Andy Fan of Boston University, who work closely with Wave 80 on porous polymer monolith extraction technologies.

About Wave 80

Wave 80 Biosciences develops next-generation molecular diagnostics instruments and consumables for human health conditions including HIV/AIDS, chlamydia, hepatitis C, and certain cancers and autoimmune diseases. Distinguished by a novel one patient-one test usage model, best-in-class performance, and a superior value proposition, Wave 80’s pipeline products address unmet needs of diverse patient populations worldwide in the high-clinical-value molecular diagnostics segment of the clinical laboratory testing systems market.